transcription 3 stat3 phosphorylation inhibitor stattic (MedChemExpress)
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transcription 3 stat3 phosphorylation inhibitor stattic
Transcription 3 Stat3 Phosphorylation Inhibitor Stattic, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 427 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat3+phosphorylation+inhibitor+stattic/Stattic/pmc13038336-98-6-15
Average 99 stars, based on 427 article reviews
Transcription 3 Stat3 Phosphorylation Inhibitor Stattic, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 427 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/stat3+phosphorylation+inhibitor+stattic/Stattic/pmc13038336-98-6-15
Average 99 stars, based on 427 article reviews
transcription 3 stat3 phosphorylation inhibitor stattic - by Bioz Stars,
2026-09
99/100 stars
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1) Product Images from "Smoking promotes colorectal cancer via the CKAP2L/AREG axis"
Article Title: Smoking promotes colorectal cancer via the CKAP2L/AREG axis
Journal: International Journal of Oncology
doi: 10.3892/ijo.2026.5872
Figure Legend Snippet: CKAP2L promotes proliferation and migration of colorectal cancer cells through the STAT3/AREG/EGFR axis. (A) Expression levels of STAT3 and p-STAT3 proteins measured by western blotting. (B) Calculation of IC 50 in HCT116 cells treated with Stattic for 24 h. (C) Levels of AREG were measured by reverse transcription-quantitative PCR and enzyme-linked immunosorbent assay. (D) Migration of cells was detected by Transwell assay (×100 magnification). (E) Proliferation of cells was measured by Cell Counting Kit 8. (F) Expression levels of proteins measured by western blotting. (G) Binding peak of STAT3 on the promoter region of AREG was detected by Cistrome Data Browser, the binding motif was predicted using the JASPAR database, and the binding of STAT3 to the AREG promoter was evaluated by chromatin immunoprecipitation assay. Data were analyzed using (A and G) Unpaired Student's t-test, and (C-F) two-way ANOVA followed by Tukey test. * P<0.05, ** P<0.01, *** P<0.001 and **** P<0.0001. AREG, amphiregulin; CKAP2L, cytoskeleton-associated protein 2-like; EGFR, epidermal growth factor receptor; NC, negative control; p-, phosphorylated; sh, short hairpin; STAT3, signal transducer and activator of transcription 3; TSS, transcription start site.
Techniques Used: Migration, Expressing, Western Blot, Reverse Transcription, Real-time Polymerase Chain Reaction, Enzyme-linked Immunosorbent Assay, Transwell Assay, Cell Counting, Binding Assay, Chromatin Immunoprecipitation, Negative Control
Figure Legend Snippet: Smoking may promote colorectal cancer progression through the CKAP2L/STAT3/AREG/EGFR axis. This figure was drawn by Figdraw ( https://www.figdraw.com/ ). AREG, amphiregulin; CKAP2L, cytoskeleton-associated protein 2-like; EGFR, epidermal growth factor receptor; STAT3, signal transducer and activator of transcription 3.
Techniques Used:
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